%0 Journal Article
%T STUDY OF THE PROLONGED RELEASE OF A DRUG FROM ENCAPSULATED GRANULES PREPARED WITH BEESWAX
%A N. A. Elechi* and H. C. Mital
%J International Journal of Pharmaceutical Sciences and Research
%D 2012
%I Society of Pharmaceutical Sciences and Research
%X The in vitro dissolution studies of encapsulated sodium salicylate granules coated with beeswax is presented. The factors investigated were the effects of concentration, presence of a hydrophilic fatty material, polyethylene glycol 6000 (PEG 6000), and technique (pan-coating, fusion and granulation) on the sustained release of drug when coated with beeswax. Comparison of release rates was based on the use of a parameter, t70% (time for 70% of drug to be released). The greater the concentration of beeswax, ranging from 13.04 to 28.75%, the more prolonged the release. The presence of PEG 6000 at a concentration of 1:9 beeswax in the coating fluid significantly (p<0.05) increased the release rate, and at a concentration of 1:1 nullified the sustained release effect of beeswax. The t70% for the fusion, granulated and pan-coated batches were in the increasing order of 25min., 1hr.35min. and 2hr.45min, respectively.
%K prolonged-release
%K beeswax
%K PEG 6000
%K pan-coating
%K fusion
%K granulation
%U http://ijpsr.com/V3I6/12%20Vol.%203,%20Issue%206,%20June%202012,%20IJPSR-1262,%20Paper%2012.pdf