%0 Journal Article
%T Method Development and validation of oseltamivir phosphate in bulk drug by UV spectroscopy
%A A. Chourasia
%A S. Acharya
%A S. k. Sahu
%J International Journal of Pharmaceutical and Biological Research
%D 2011
%I 
%X The present research work discussed the development of a simple, sensitive, rapid, accurate, precise and economical UV Spectrophotometric method for the Validation of Oseltamivir Phosphate in bulk and pharmaceutical dosage form which is based on the measurement of absorption maxima at 217 nm. Double beam U.V visible spectrophotometers, Shimadzu, Kyoto, Japan. Model UV1800 with 1cm matched quartz cells and de-ionized water as solvent were used. Developed methods obeyed the Beer¡¯s law in the concentration range of16 to 24¦̀g/ml having line equation y = 0.015x + 0.251 with correlation coefficient of 0.999. Method was validated statistically. Percentage recovery of the drug for the proposed method ranged from (98.76%) indicating no interference of the excipients. The developed method was validated with respect to linearity, precision, accuracy (recovery), limit of detection (LOD) and limit of quantitation (LOQ).
%K Oseltamivir
%K Phosphate(OP)
%K deionised water
%K Absorbance maxima
%U http://www.kejapub.com/ijpbr/docs/IJPBR11-02-05-32.pdf