%0 Journal Article
%T Evaluation of Antidiarrhoeal Potential of the Ethanolic Extract of Three Bangladeshi Medicinal Plants
%A Hemayet Hossain
%A Shubhra Kanti Dey
%A Arpona Hira
%A Md. Sariful Islam Howlader
%J International Journal of Pharmaceutical and Phytopharmacological Research
%D 2012
%I International Journal of Pharmaceutical and Phytopharmacological Research
%X The present study was designed to investigate the antidiarrhoeal activity as well as phytochemical screening of ethanolic extract of three Bangladeshi medicinal plants namely Diospyros blancoi A. DC (leaf), Acacia nilotica Linn. (bark) and Hibiscus sabdariffa Linn. (seed and calyxes). The ethanol extracts at graded doses (250 and 500 mg/kg body weight) was investigated for antidiarrhoeal activity in acetic acid induced writhing model in mice. Diospyros blancoi leaf extract significantly (p<0.001)inhibited the mean number of defecation which were 33.19% and 45.28% at the doses of 250 and 500mg/kg respectively. The latent period was increased and number of stools for the extract treated group was significantly (p<0.001) decreased as compared to control group. The result was found comparable to the effect of standard antidiarrhoeal drug loperamide (62.26% at the dose of 3mg/kg). The bark extract of Acacia nilotica at the dose of 500mg/kg body weight produced 32.64% inhibition of defecation. The percent inhibition of the ethanol extract of Hibiscuss sabdariffa calyxes and seed extracts were found to be (16.98% and 11.32%) at the dose of 250mg/kg and (24.53% and 20.75%) at the doses of 500mg/kg body weight respectively. Phytochemical analysis of the extract of these three Bangladeshi medicinal plants indicated the presence of reducing sugar, gum, tannin and alkaloid types of compounds. Therefore, the obtained results tend to suggest the antidiarrhoeal activities of the crude ethanolic extract of the leaves of Diospyros blancoi A. DC and that of bark of the Acacia nilotica Linn. thus provide the scientific basis for the traditional uses of these plants as modality for diarrhea.
%K Antidiarrhoeal activity
%K Acacia nilotica
%K Diospyros blancoi
%K Hibiscus sabdariffa
%U http://www.eijppr.com/may_jun_2012/9.pdf