%0 Journal Article
%T Antihyperlipedemic A ctivity of Woodfordia fruticosa E xtract in High Cholesterol Diet Fed Mice
%A Nishu Khera
%A Aruna Bhatia
%J International Journal of Pharmaceutical and Phytopharmacological Research
%D 2013
%I International Journal of Pharmaceutical and Phytopharmacological Research
%X The aim ofthe present study was to investigate the potential role of methanolic flower extract of Woodfordia fruticosa in loweringlipid parameters in mice fed a high cholesterol diet. Swiss albino mice were randomly divided into five groups of six and wereadministered either: 0.5 ml water (negative controls); 30 mg cholesterol (hypercholesterolemic animals); MEWF (methanolicextract of Woodfordia fruticosa flowers) at 400mg/kg body weight (positive control); or the same doses of both cholesterol andthe extract (test animals); Atorvastatin at 10mg/kg body weight (drug control). The effects of MEWF on the lipid profile wereassessed by measuring concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-c),high-density lipoprotein cholesterol (HDL-c), and very low-density lipoprotein cholesterol (VLDL-c). Administration ofcholesterol showed significant elevation (p < 0.001) of TC, LDL-c, VLDL-c, and TG concentrations, and of the TC: HDL-c ratio(p < 0.05). Administration of MEWF extract in cholesterol fed mice caused a significant decrease (p < 0.001) in theconcentrations of serum TC, LDL, VLDL TGs as well as TC: HDL-c ratio when compared with cholesterol fed control mice andresults were also comparable to that of drug control group. These results suggest lipid-lowering effects of, Woodfordia fruticosawhich serves as a new potential natural product for preventing hyperlipidemia.
%K Woodfordia fruticosa
%K Swiss albino mice
%K Hyperlipidemia
%K Atorvastatin
%U http://www.eijppr.com/nov-dec2012/13.pdf