%0 Journal Article
%T Histological and Biochemical Alterations on Oral Administration of Artesunate on the Testis of Male Mice
%A Dhrupadsinh K Rajput
%A Deval S Mehta
%A Dr.Linz-Buoy George
%A Dr.Ketki R Desai
%J International Journal of Pharmaceutical and Biological Research
%D 2012
%I 
%X Malaria is a global problem with the greatest burden of disease and mortality occurring in tropical and subtropical regions, especially in developing countries. The present study is focused to screen Artesunate toxicity in testis of male albino mice of Swiss Strain. Artesunate is a semi-synthetic water-soluble derivative of artemisinin generally used to treat chloroquine resistant malaria. Oral doses of 150mg/kg.b.wt and 300mg/kg.b.wt were administered for a period of 14, 21 and 45 days. Effects were observed on some specificparameters like 3¦Â hydroxysteroid dehydrogenase, 17¦Â hydroxysteroid dehydrogenase, cholesterol, protein and histology of concerned tissue using standard methods. The results of present investigation revealed that Artesunate caused significant alterations in a dose dependent manner. The histological findings after H&E staining indicated that the treated section of the testis showed some varying degree of cell clustering, cellular hypertrophy and intercellular vacuolations specifically in the germinal cell layer, resulting in a decline in sperm production. The germinal cell nuclei were highly pyknotic. Vacuolization within the interstitium was also observed particularly in the Leydig cell cytoplasm.
%K Antimalarial Drug
%K Artesunate
%K Biochemical estimation
%K H&E staining
%K Testis
%K Toxicity.
%U http://www.kejapub.com/ijpbr/docs/IJPBR12-03-03-34.pdf