%0 Journal Article
%T New Method for Synthesis of 3-(4-hydroxy-3-methoxyphenyl) prop-2-enoic acid and 1- feruloyl-¦Â-D-glucose
%A Kunal M. Gokhale
%J International Journal of Pharmaceutical and Phytopharmacological Research
%D 2011
%I International Journal of Pharmaceutical and Phytopharmacological Research
%X Ferulic acid and its esters with polyhydroxy compounds have been tested for LDL-Cholesterol lowering, tumor suppressor activities and also have chemopreventive role in development of cancer. The conventional methods to obtain Ferulic acid [3-(4-hydroxy-3-methoxy phenyl) prop-2-enoic acid], a member of caffeic acid family, from natural resources are expensive whereas available synthetic methods suffer from limitations like long reaction time and low yield. 3-(4-hydroxy-3-methoxy phenyl) prop-2-enoic was synthesized using Cu(I)CN and tert-butylhypohalite with better yield. The reaction was carried out at ambient temperature and also involves simple work up. 1-Feruloyl-¦Â-D-glucose, a substrate for serine carboxypeptidases was also synthesized with overall yield of 85%.
%K Ferulic acid
%K 3-(4-hydroxy-3-methoxy phenyl) prop-2-enoic acid
%K tert-Butylhypohalite
%K Cu(I) CN
%K 1- Feruloyl-¦Â-D-glucose
%U http://www.eijppr.com/4%20New%20Method%20for%20Synthesis%20of%203%204%20hydroxy%203%20methoxyphenyl%20%20prop%202%20enoic%20acid%20and%201%20%20feruloyl%20%DF%20D%20glucose.pdf