%0 Journal Article
%T Evaluation of Anticonvulsant Activity of Ethanolic Extract of Vitex nigundo in Swiss Albino Rats
%A Dr.Jayasree.T
%A Miss Arpitha.T
%A DR.Kavitha.R
%A Dr.Kishan.PV
%J International Journal of Pharmaceutical and Phytopharmacological Research
%D 2012
%I International Journal of Pharmaceutical and Phytopharmacological Research
%X Vitex-negundo Linn (Verbenaceae), a large aromatic shrub with typical five foliolate leaves pattern has been claimed to possess anticonsulvant activity apart from many medicinal properties. Maximal electroshock seizures (MES) in albino rats were used to study anticonvulsant activity of Vitex-negundo leaf extract. The ethanol leaf extract of Vitex-negundo was administered orally in graded doses (500 and 1000 mg/kg and 2000mg/kg p.o ) in the experimental model and the effects were compared with Diphenylhydantoin in MES method as standard and normal saline as control. The Vitex-negundo in the doses 1000 mg/kg has significant effect and 2000mg/kg p.o showed protection against MES to a highly significant extent. Test drug in the dose (1000 mg/kg, po) showed 60% protection in clonic seizures. It also decreased number and duration of convulsions significantly.These findings suggested that Vitex-negundo possesses anticonvulsant activity against MES induced convulsions. Vitex-negundo may be useful as an adjuvant therapy along with standard anticonvulsants and can possibly lower the requirement of Diphenylhydantoin and other anti convulsant drugs, Ethanol leaf extract of vitex ningundo significantly (P<0.01) decreased the duration of tonic extensor phase in MES-induced seizures. TheVitex-negundo extract showed a maximum inhibition (80% mortality) against MES-induced seizures.Thus, it has been concluded that ethanolic extract of Vitex-negundo possesses anti-epileptic activity.
%K Antiepileptic
%K Vitex-negundo
%K Electroconvulsiometer
%K Maximum Electroshock (MES)
%K Verbenaceae
%U http://www.eijppr.com/march-2012/5.pdf