%0 Journal Article
%T Half-Saline versus Combined Normal Saline and 1/3¨C2/3 Intravenous Fluid Therapy in Kidney Transplantation
%A A. Ghorbani
%A M. Feli
%A A. Ehsanpour
%A H. Shahbazian
%J International Journal of Organ Transplantation Medicine
%D 2011
%I Avicenna Organ Transplantation Institute
%X Background: Sufficient intravascular volume should be established for optimal graft function after renal transplantation. However, there is no recommendation for the type of fluid therapy post-operatively. We compared half-saline vs. normal saline and 1/3¨C2/3 intravenous fluid replacement after renal transplan tation. Methods: We enrolled all patients who underwent kidney transplantation between June 2008 and March 2010 in Golestan Hospital, Ahwaz, southwestern Iran. Patients were randomly divided into two groups using a blinded allocation technique. Group A patients (Case) received half saline, and group B patients (Control) received normal saline and 1/3¨C2/3 intravenous fluid. According to our protocol, we replaced as much as 100% of hourly urine output in the first day, followed by 90% and 70% of every 2-hour urine output in the 2nd and 3rd days, respectively. Blood pressure and pulse rate were recorded hourly. Serum sodium, potassium, creatinine and pH were assessed twice a day. Results: There were 34 and 36 eligible patients in the case and control groups, respectively. The mean¡ÀSD 6-hour urine output in the first 5 days after surgery was 2586¡À725 mL in the control group and 2764¡À758 mL in the case group (p=0.31). The mean¡ÀSD serum creatinine level at the end of the 5th post-operative day was 1.3¡À0.5 and 1.4¡À0.7 mg/dL in the case and control groups, respectively (p=0.56). Serum creati nine level did not reduce to 1.5 mg/dL or lower in 6 of 36 control subjects and in 4 of 34 cases at the end of the 5th day (p=0.558). The mean¡ÀSD time to creatinine level <1.5 mg/dL was 1.3¡À1 days in the control group and 1.7¡À0.8 days in the case group (p=0.635). Hyperkalemia occurred in 3 of 36 patients in the control group and in 2 of 34 patients in the case group (p=0.318). The incidence of hyponatremia in the control group was 11% (4 of 36 patients) vs no patients in the case group (p=0.115). Conclusion: Either half-saline or normal saline and 1/3¨C2/3 intravenous solution can be safely used as fluid replacement therapy after kidney transplantation.
%K Renal transplantation
%K Intravenous fluid therapy
%K Renal function
%U http://home.sums.ac.ir/~habibzaf/ojs/index.php/IJOTM/article/view/76/139