%0 Journal Article
%T A novel role of proteasomal ¦Â1 subunit in tumorigenesis
%A Fuqiang Yuan
%A Yana Ma
%A Pan You
%A Wenbo Lin
%J Bioscience Reports
%D 2013
%I Portland Press, Biochemical Society
%R 10.1042/bsr20130013
%X p27Kip1 is a key cell-cycle regulator whose level is primarily regulated by the ubiquitin¨Cproteasome degradation pathway. Its ¦Â1 subunit is one of seven ¦Â subunits that form the ¦Â-ring of the 20S proteasome, which is responsible for degradation of ubiquitinated proteins. We report here that the ¦Â1 subunit is up-regulated in oesophageal cancer tissues and some ovarian cancer cell lines. It promotes cell growth and migration, as well as colony formation. ¦Â1 binds and degrades p27Kip1directly. Interestingly, the lack of phosphorylation at Ser158 of the ¦Â1 subunit promotes degradation of p27Kip1. We therefore propose that the ¦Â1 subunit plays a novel role in tumorigenesis by degrading p27Kip1.
%K degradation
%K p27Kip1
%K phosphorylation
%K tumorigenesis
%K ¦Â1 subunit
%U http://www.bioscirep.org/bsr/033/e050/bsr033e050.htm