%0 Journal Article %T Long-Term Gynecological Outcomes in Women with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency %A Johannsen TH %A Ripa CPL %A Carlsen E %A Starup J %J International Journal of Pediatric Endocrinology %D 2010 %I BioMed Central %R 10.1186/1687-9856-2010-784297 %X Background. Our knowledge on long-term outcome in CAH remains incomplete. Methods. In a prospective study (33 CAH patients, 33 age-matched controls), reproductive outcomes, self-rating of genital appearance and function, and sexuality were correlated to degree of initial virilisation, genotype, and surgery. Results. Patients had larger median clitoral lengths (10.0 mm [range 2每30] versus 3.5 [2每8], ), shorter vaginal length (121 mm [100每155] versus 128 [112每153], ), lower uterine volumes (29.1 ml [7.5每56.7] versus 47.4 [15.9每177.5], ), and higher ovarian volumes (4.4 ml [1.3每10.8] versus 2.8 [0.6每10.8], ) than controls. Satisfaction with genital appearance was lower and negatively correlated to degree of initial virilisation (). More patients had never had intercourse (), and age at 1st intercourse was higher (18 yrs versus 16 yrs, ). Conclusion. Despite overall acceptable cosmetic results, reproductive outcomes were suboptimal, supporting that multidisciplinary teams should be involved in adult follow up of CAH patients. %U http://www.ijpeonline.com/content/2010/784297