%0 Journal Article
%T Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes
%A Hongpeng He
%A Mei£¿Chin Lee
%A Li£¿Ling Zheng
%A Lei Zheng
%J Bioscience Reports
%D 2013
%I Portland Press, Biochemical Society
%R 10.1042/bsr20120059
%X The concept of one-protein¨Cmultiple-function, i.e. moonlighting proteins, is an ever-expanding paradigm. We obtained compelling evidence that an array of ¡®cytoplasmic¡¯ metabolic enzymes can enter the nuclei to carry out moonlighting transcription functions; this phenomenon is conserved from Drosophila to humans. Of particular interest are the classical glycolytic enzymes GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and LDH (lactate dehydrogenase), which utilize NAD(H) as coenzymes and not only moonlight (in their nuclear forms) to regulate the transcription of S-phase-specific histone genes, but also act as metabolic/redox sensors that link histone gene switching to DNA replication and S-phase progression.
%K chromosome
%K enzyme
%K GAPDH
%K histone 2B
%K S-phase
%U http://www.bioscirep.org/bsr/033/e018/bsr033e018.htm