%0 Journal Article
%T Salvage concurrent radio-chemotherapy for post-operative local recurrence of squamous-cell esophageal cancer
%A Jian Zhang
%A Feng Peng
%A Na Li
%A Yongmei Liu
%A Yong Xu
%A Lin Zhou
%A Jin Wang
%A Jiang Zhu
%A Meijuan Huang
%A Youling Gong
%J Radiation Oncology
%D 2012
%I BioMed Central
%R 10.1186/1748-717x-7-93
%X 50 patients with loco-recurrent squamous-cell cancer after curative esophagectomy were retrospectively analyzed. Patients were treated with radiotherapy (median 60£¿Gy) combined with chemotherapy consisting of either 5-fluorouracil (5-FU) plus cisplatin (DDP) (R-FP group) or paclitaxel plus DDP (R-TP group).The median follow-up period was 16.0£¿months. The 1-year and 3-year survival rates were 56% and 14%, respectively. The median progression-free survival (PFS) and overall survival (OS) time was 9.8 and 13.3£¿months respectively. There was no statistical significance of the PFS of the two groups. The OS (median 16.3£¿months) in the R-TP group was superior to that in the R-FP group (median: 9.8£¿months) (p£¿=£¿0.012). Among the patients who had received ¡Ý60£¿Gy irradiation dose, the median PFS (10.6£¿months) and OS (16.3£¿months) were significantly superior to the PFS (8.7£¿months) and OS (11.3£¿months) among those patients did not (all p£¿<£¿0.05). Grade 3 treatment-related gastritis were observed in 6 (27.3%) and 7 (25%) patients in the R-FP and R-TP group respectively. By univariate survival analysis, the age (<60£¿years), TP regimen and higher irradiation dose might improve the OS of such patients in present study.For those patients with post-operative loco-recurrent squamous-cell esophageal carcinoma, radiotherapy combined with either FP or TP regimen chemotherapy was an effective salvage treatment. Younger age, treatment with the TP regimen and an irradiation dose ¡Ý60£¿Gy might improve the patients¡¯ treatment outcome.
%K Squamous-cell esophageal cancer
%K Post-operative local recurrence
%K Salvage radio-chemotherapy
%K Treatment outcomes
%K Toxicity
%U http://www.ro-journal.com/content/7/1/93/abstract