%0 Journal Article
%T IL-10 gene promoter polymorphisms and leprosy in a Colombian population sample Polimorfismos en el gen promotor de IL-10 en una muestra de pacientes colombianos con lepra
%A Nora Mar赤a Cardona-Castro
%A Miryan Margot S芍nchez-Jim谷nez
%A Winston Rojas
%A Gabriel Bedoya-Berr赤o
%J Biom谷dica
%D 2011
%I Instituto Nacional de Salud
%X Introduction. Polymorphisms in promoters of genes code for cytokines that affect transcription levels, which have been reported in leprosy patients with functional and clinical implications. Objective. Detect the polymorphism in the promoter of IL10 gene of the SNPs (Single nucleotide polymorphism) -1082 A/G (rs1800896), -819C/T (rs1800871), and -592A/C (rs1800872) in 100 leprosy patients and in a control group of 100 volunteers from a leprosy endemic region of Colombia. Results. The genotypes C/C and C/T in the SNP -819 together, were associated with leprosy (OR 4.34 p=1x10-3) and in the same way, the genotypes C/C and C/A in the -592 SNP showed association (OR = 4.3 p=1x10-3). The haplotypes -819C-519C and -1082A-819C-592C showed significant association (OR=4.34 p=1x10-3 and OR=6.25 p=5x10-4) respectively. These haplotypes in homozygosis conditions are also associated to leprosy, -819C-519C/-819C-519C (OR=4.34 p=1x10-3), -1082A -819C-592C/-1082A -819C-592C (OR=1.90 p=0.04). The SNP -1082 was not associated with leprosy in this population. Conclusions. The haplotype that we found associated with leprosy, -1082A-819C-592C/-1082A-819C-592C, had been reported as low producer of IL-10. Functionally this low production of IL-10 may have immune response consequences and clinical implications. Different haplotypes of IL-10 had been reported as markers for leprosy susceptibility or resistance in other populations, which suggest that differences in distribution of diverse IL-10 gene polymorphisms between ethnic groups are an important factor in determining gene disease association. Introducci車n. Los polimorfismos en genes promotores que codifican para citocinas y que afectan los niveles de transcripci車n, han sido reportados en pacientes con lepra con implicaciones cl赤nicas y funcionales. Objetivo. Detectar los polimorfismos en el gen promotor de IL10, de los SNP (polimorfismo de un solo nucle車tido) -1082 A/G (rs1800896), -819C/T (rs1800871), y -592A/C (rs1800872) en 100 pacientes con lepra y un grupo control de 100 voluntarios, de una regi車n end谷mica de Colombia. Resultados. Los haplotipos -819C-519C y -1082A-819C-592C mostraron asociaci車n significativa con lepra (OR=4,34 p=1x10-3 y OR=6,25 p=5x10-4) respectivamente. Estos haplotipos en condiciones homocig車ticas, est芍n tambi谷n asociados con lepra -819C-519C/-819C-519C (OR=4,34 p=1x10-3), -1082A -819C-592C/-1082A -819C-592C (OR=1,90 p=0.04). El SNP -1082 no se encontr車 asociado con lepra en esta poblaci車n. Los genotipos C/C y C/T en el SNP -819, se encontraron asociados a lepra (OR 4,34 p=1x10-3), de igual maner
%K Lepra
%K Lepra Multibacilar
%K Lepra Paucibacilar
%K Lepra Lepromatosa
%K IL-10
%K Citocinas
%K Regiones Promotoras Gen谷ticas
%K Polimorfismo de Nucle車tido Simple.
%U http://www.revistabiomedica.org/index.php/biomedica/article/view/386