%0 Journal Article
%T Reliability and agreement of two smear reading scales for classification and monitoring of multidrug therapy in leprosy patients Confiabilidad y concordancia de dos escalas de lectura de baciloscopias para clasificaci車n y seguimiento del tratamiento con m迆ltiples medicamentos de los pacientes con lepra
%A Claudia Luc赤a Colorado
%A Guillermo S芍nchez
%A Martha In赤rida Guerrero
%A Clara In谷s Le車n
%J Biom谷dica
%D 2011
%I Instituto Nacional de Salud
%X Introduction. After the clinical diagnosis of leprosy, classification methods are necessary to define a treatment and prognosis of patients consistent with bacterial load. Bacteria are detected in skin smear, and bacterial load typically is established by the internationally used Ridley's logarithmic scale, However, in Colombia an alternative semiquantitative scale is used. Objective. The interobserver reproducibility was established for the Ridley and Colombia scales, and the level of correlation-matching was identified between the bacillary indices obtained in order to assess the degree of interchangeability. Materials and methods. Standardization was attained by a reading of the smears by 2 readers with subsequent, blinded evaluation of inter-observer agreement. Each reader quantified the bacterial load of for each sample (n=325) using the Colombian and the Ridley scales. The degree of interobserver agreement was assessed with weighted kappa coefficient. The level of correlation and agreement between the measurements of the bacillary index was established with coefficient of Lin. Results. The interobserver weighted kappa coefficient was 0.83 for the Colombia scale and 0.85 for the Ridley scale. The Lin coefficient was 0.96 for the correlation-matching of bacillary indexes. Conclusions. Interobserver agreement obtained for both scales was excellent as the correlation-matching bacillary indices determined with both methods. With the cut-off points yielded a good level of agreement, ensuring interchangeability between the scales defining the high or low bacterial load. Introducci車n. El diagn車stico de la lepra es cl赤nico pero requiere m谷todos de clasificaci車n para establecer el tratamiento y el pron車stico de los pacientes, acordes con su carga bacilar; 谷sta se detecta en extendidos de piel y se establece mediante la escala logar赤tmica de Ridley. En Colombia se emplea una escala semicuantitativa. Objetivo. Establecer la reproducibilidad entre observadores para las dos escalas y establecer el nivel de correlaci車n de la concordancia entre el 赤ndice bacilar obtenido con la escala colombiana y con la de Ridley, para evaluar cu芍nto se pueden intercambiar. Materiales y m谷todos. Se estandariz車 la lectura de las baciloscopias por dos lectores, con posterior evaluaci車n del acuerdo entre observadores en un ensayo ciego. Cada lector cuantific車 la carga bacilar de las muestras, usando la escala colombiana y la internacional. El grado de concordancia entre observadores se evalu車 con el coeficiente kappa ponderado. El nivel de correlaci車n de la concordancia entre las me
%K lepra/clasificaci車n
%K terap谷utica
%K escalas
%K Colombia
%U http://www.revistabiomedica.org/index.php/biomedica/article/view/383