%0 Journal Article
%T Evaluation of the seroconversion as a response to rabies vaccination in dogs, Valle del Cauca, Colombia, 2009 Evaluaci車n de la seroconversi車n como respuesta a la vacunaci車n antirr芍bica en perros en el departamento del Valle del Cauca, Colombia, 2009
%A Andr谷s P芍ez
%A Constanza Hern芍ndez
%A Humberto Escobar
%A John Jairo Zapata
%J Biom谷dica
%D 2011
%I Instituto Nacional de Salud
%X Introduction. The province of Valle del Cauca has been free of dog rabies for more than 20 years. However, sylvatic rabies foci remain which are threats to the health of the populace and its pets. Rabies vaccination campaigns are carried out annually in all 42 counties of the province. Objectives. The impact of dog vaccination was evaluated on the basis of humoral immunoresponse, population parameters and correlation with variables inherent to the vaccination process and logistics. Materials and methods. Sera and associated data were obtained from each of the 42 counties for a total sample of 569 rabies-vaccinated dogs. Rabies neutralizing antibodies were measured by quantitative ELISA. The data were analyzed with the statistical programs in Epi-Info 6.0. Results. Nearly 10% of dogs were seronegative (9.1%) and an additional 25.1% did not elicit an adequate humoral immune response to vaccination. Concentration of rabies neutralizing antibodies diminished gradually with the time after vaccination and was correlated with dog age and vaccine quality. No associations were noted between dog gender or breed. Conclusions. These data permit the following recommendations: (1) only viable, non expired rabies vaccines must be used to immunize animals, (2) two doses of rabies vaccine must be applied during the first six months of dog life, (3) booster immunizations must be administered every year, (4) practices and processes related to rabies vaccination in private institutions must inspected regularly by health authorities. Introducci車n. El departamento del Valle del Cauca ha estado libre de rabia canina por m芍s de 20 a os, aunque persisten focos de rabia silvestre que amenazan a humanos y sus mascotas; por ello, como medida preventiva. se realizan anualmente campa as de vacunaci車n antirr芍bica canina. Objetivos. Medir el impacto de la vacunaci車n en t谷rminos de seroconversi車n de anticuerpos neutralizadores y de porcentaje de perros con respuesta inmunitaria humoral adecuada, relacionando variables propias de estos animales y de las condiciones de vacunaci車n. Discutir el significado epidemiol車gico de los resultados y sus implicaciones en salud p迆blica. Materiales y m谷todos. Se obtuvo suero e informaci車n de 569 perros vacunados en los 42 municipios de Valle del Cauca. La inmunidad humoral se investig車 por ELISA cuantitativa. La informaci車n se analiz車 con el programa Epi-Info 6.0. Resultados. El 9,1 % de los perros de la muestra fueron seronegativos y el 25,1 % no evidenciaron respuesta inmunitaria humoral adecuada a la vacunaci車n. La concentraci車n de anticuerpos dismi
%K vacunas antirr芍bicas
%K virus de la rabia
%K Lyssavirus
%K zoonosis
%K vigilancia epidemiol車gica
%K inmunidad
%K Colombia
%U http://www.revistabiomedica.org/index.php/biomedica/article/view/395