%0 Journal Article
%T In vitro cytotoxic activity of Cymbopogon citratus L. and Cymbopogon nardus L. essential oils from Togo
%A Koffi Koba
%A Sanda Komla
%A Guyon Catherine
%A Raynaud Christine
%J Bangladesh Journal of Pharmacology
%D 2009
%I Bangladesh Pharmacological Society
%X The leaf essential oils of Cymbopogon citratus L. and Cymbopogon nardus L.(Poaceae) from Togo were steam-distilled, analyzed for percentage composition and investigated in vitro for their potential cytotoxic activity on human epidermic cell line HaCat. The percentage composition showed that the main constituents of essential oils samples were respectively geranial (45.2%), neral(32.4%) and myrc¨¨ne (10.2%) for C. citratus essential oil and citronellal (35.5%), geraniol (27.9%) and citronellol (10.7%) for that of C. nardus. The in vitro cytotoxicity bioassays on human epidermic cell line HaCaT revealed that the toxicityof the essential oil from C. citratus (IC50: 150 ¦ÌL.mL-1) was higher than that of the essential oil from C. nardus (IC50: 450 ¦ÌL.mL-1). Pure commercial neral, geranial, and citronellal standards showed respectively the following IC50 values: 100, 250 and 300 ¦ÌL.mL-1). Conversely, pure citronellol standard appeared almost non-toxic (IC50>1000 ¦ÌL.mL-1), proving the major role played in synergyby neral and geranial in the overall toxicity showed by the citratus oil sample tested in this work.
%K Cymbopogon citratus
%K Cymbopogon nardus
%K Cytotoxicity
%K Essential oil
%K HaCaT cell line
%U http://www.bdjpharmacol.com/0401/29.pdf