%0 Journal Article
%T n vitro H1-receptor antagonist activity of methanolic extract of tuber of Stephania glabra
%A Nisar Ahmad Khan
%A Dinesh Kumar
%A Zulfiqar Ali Bhat
%A Vijender Kumar
%A Navneet Nagpal and Santosh S. Bhujbal
%J Bangladesh Journal of Pharmacology
%D 2010
%I Bangladesh Pharmacological Society
%X In the present study, methanolic extract of tuber of Stephania glabra was evaluated for H1-bloker activity by employing in vitro screening models of guinea pig ileum and goat tracheal chain preparation. Goat isolated trachea and guinea pig ileum contracted to histamine in a dose-dependent manner while chlorpheniramine blocked this effect. The methanolic extract produced significant dose-dependent H1-receptor antagonist activity by blocking histamine-induced contraction.
%K H1-receptor antagonist
%K Goat tracheal chain
%K Guinea pig ileum
%K Stephania glabra
%U http://www.banglajol.info/index.php/BJP/article/view/6671/5406