%0 Journal Article
%T Anticonvulsant activity of bioflavonoid gossypin
%A Duraisami Rasilingam
%A Srinivasan Duraisamy
%A Ramaswamy Subramanian
%J Bangladesh Journal of Pharmacology
%D 2009
%I Bangladesh Pharmacological Society
%X The anticonvulsant activity of gossypin was investigated by studying the effects on seizures induced by pentelentetrazole, strychnine and maximal electroshock convulsive methods in mice. Gossypin (10 and 20 mg/kg) significantly reduced the duration of convulsion in tonic seizure induced by pentelenetetrazole (95 mg/kg, intraperitoneally). Gossypin (20 mg/kg p.o) significantly reduced the tonic extensor convulsion induced by strychnine and maximum electroshock-induced convulsions. The data obtained suggest that gossypin have anticonvulsant property and may probably be affecting both GABA aminergic and glycine inhibitory mechanism.
%K Anticonvulsant
%K Bioflavonoid
%K Gossypin
%K Pentelenetetrazole
%K Strychnine
%U http://www.bdjpharmacol.com/0401/51.pdf