%0 Journal Article
%T Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular joint. Part II: mandibular growth
%A Peter Stoustrup
%A Kasper D Kristensen
%A Annelise K¨¹seler
%A Thomas K Pedersen
%A John Gelineck
%A Troels Herlin
%J Pediatric Rheumatology
%D 2009
%I BioMed Central
%R 10.1186/1546-0096-7-6
%X Arthritis was induced and maintained in the TMJs of 10-week old pre-sensitized rabbits (n = 42) by four repeated IA TMJ injections with ovalbumin, over a 12-week period. One group was treated weekly with systemic etanercept (0.8 mg/kg) (n = 14), another group (n = 14) received IA etanercept (0.1 mg/kg) bilaterally one week after induction of arthritis and one group (n = 14) served as an untreated arthritis group receiving IA TMJ saline injections. Head computerized tomographic scans were done before arthritis was induced and at the end of the study. Three small tantalum implants were inserted into the mandible, serving as stable landmarks for the super-impositions. Nineteen variables were evaluated in a mandibular growth analysis for inter-group differences. All data was evaluated blindedly. ANOVA and T-tests were applied for statistical evaluation using p < 0.05 as significance level.Significant larger mandibular growth disturbances were observed in the group receiving IA saline injections compared with the systemic etanercept group. The most pronounced unfavourable posterior mandibular rotation pattern was observed in the group receiving IA saline injections.Intervention with systemic etanercept monotherapy equivalent to the recommended human dose allows a mandibular growth towards an original morphology in experimental TMJ arthritis. Systemic administrations of etanercept are superior to IA TMJ administration of etanercept in maintaining mandibular vertical growth.Temporomandibular joint (TMJ) arthritis in growing individuals severely affects the endochondral ossification in the condylar cartilage responsible for a substantial part of the mandibular growth [1,2]. The intracapsular location of this growth cartilage is a unique characteristic of the TMJ and it makes this joint vulnerable to inflammatory changes. It is evident that the pronounced mandibular growth deviations seen in juvenile idiopathic arthritis (JIA) patients is a consequence of TMJ arthritis [3-5]
%U http://www.ped-rheum.com/content/7/1/6