%0 Journal Article
%T Frequency of the changes in the serum immunoglobulins levels of the patients attended at the University Hospital, Londrina, Paran¨¢ Freq¨¹¨ºncia das altera  es dos n¨ªveis s¨¦ricos de imunoglobulinas dos pacientes atendidos no Hospital Universit¨¢rio, Londrina, Paran¨¢
%A Ana Paula Kallaur
%A Gabriela Amaral Buqui
%A Guilherme Cristiani Sabino
%A Rosiane Batista Mastellari
%J Semina : Ci¨ºncias Biol¨®gicas e da Sa¨²de
%D 2007
%I Universidade Estadual de Londrina
%X The immunoglobins constitute a group of glycoproteins detected in the serum and body fluids and are produced by the B-activated lymphocytes that are differentiated in the plasma cells. They are divided into five distinct classes or isotypes: IgG, IgA, IgM, IgD, and IgE. The aim of this study was to evaluate the frequency of changes in the serum levels of immunoglobins in patients attended at the University Hospital (HU), in Londrina, Paran¨¢, assayed during the period from August 2001 to February 2006, by the nephelometry method. The immunoglobin levels were evaluated in 773 serum samples: 410 samples (53.0%) were from female patients and 363 (47.0%) from male patients, with ages ranging from one month to 86 years old. Among the 1719 serum evaluations, the IgA was evaluated in 568 serum samples and changes were observed in 88 (15.5%) of them. Among 495 IgG evaluations, 107 (21.6%) showed changes in the serum levels. The IgM was evaluated in 465 serum samples and 142 (30.5%) showed increased levels. The IgE was evaluated in 191 samples and 129 (67.5%) presented increased serum levels. The results obtained confirm the occurrence of different changes in the serum immunoglobin levels and the importance of this laboratory evaluation for the diagnosis of the infectious, allergic, and autoimmune diseases, and the congenital or acquired humoral immunodeficiencies. As imunoglobulinas constituem um grupo de glicoprote¨ªnas presentes no soro e nos l¨ªquidos organico se s o produzidas pelos linf¨®citos B ativados que se diferenciam em plasm¨®citos. S o divididas em cinco classes ou isotipos: IgG, IgA, IgM, IgD e IgE. O objetivo deste trabalho foi determinar a freq¨¹¨ºncia das altera  es dos n¨ªveis s¨¦ricos das imunoglobulinas nos pacientes atendidos pelo Hospital Universit¨¢rio (HU), Londrina, PR, no per¨ªodo de agosto de 2001 a fevereiro de 2006, avaliados pelo m¨¦todo de nefelometria. Foram analisadas 773 amostras de soro de pacientes, 410 (53,0%) do sexo feminino e 363 (47,0%) do sexo masculino, com idade variando de um m¨ºs a 86 anos. Das 1719 dosagens de imunoglobulinas s¨¦ricas realizadas, os n¨ªveis de IgA s¨¦rica foram avaliados em 568 amostras e foram observadas altera  es em 88 (15,5%) das amostras. Das 495 dosagens de IgG, 107 (21,6%) estavam com os n¨ªveis s¨¦ricos alterados. A dosagem de IgM s¨¦rica foi realizada em 465 amostras e 142 (30,5%) estavam com os n¨ªveis s¨¦ricos alterados. Os n¨ªveis de IgE s¨¦rica foram avaliados em 191 amostras e 129 (67,5%) amostras apresentaram n¨ªveis aumentados. Os dados obtidos confirmam a ocorr¨ºncia de diferentes altera  es nos n¨ªveis s¨¦r
%K Imunoglobulinas
%K Mieloma m¨²ltiplo
%K Imunodefici¨ºncias
%K Imunidade humoral
%U http://www.uel.br/revistas/uel/index.php/seminabio/article/view/3487