%0 Journal Article
%T Human T-Cell Lymphotropic Virus Type I (HTLV-1): implications for autoimmune diseases V赤rus linfotr車pico de c谷lulas T humano tipo 1 (HTLV-1): implica  es em doen as autoimunes
%A Patricia Midori Murobushi Ozawa
%A D那nis Augusto Santana Reis
%A Mirian Ayumi Kurauti
%A Tuane Mayara Gov那a Simˋes
%J Semina : Ci那ncias Biol車gicas e da Sa迆de
%D 2012
%I Universidade Estadual de Londrina
%X Autoimmunity is characterized by tissue destruction that implicates functional damages caused by self-reactive cells that escape self-tolerance mechanisms. Autoimmune diseases can be initiated by viral infections and the study of the association between these viruses and autoimmunity has advanced the understanding of the molecular mechanisms involved in autoimmune diseases. The Human T-Cell Lymphotropic Virus Type I (HTLV-1) is a deltavirus that infects preferentially lymphocytes. Retrovirus particles like has been identified in patients with autoimmune diseases. Therefore this review had by objective approach the main aspects involving HTLV-1 with systemic lupus erythematosus and rheumatoid arthritis. Studies show that retroviruses can integrate their genetic material in host DNA, changing the expression gene profile related with apoptosis and immunologic system molecules. It＊s known that HTLV-1 can cause different clinical manifestations in their careers and the mechanisms that triggers the HTLV-1 associated autoimmune diseases are not well known. Besides the perpetuation and marked production of pro-inflammatory cytokines, studies have demonstrated that both Th17 cells and T regulatory cells (Tregs) are involved in autoimmune diseases pathogenesis. Therefore the HTLV-1 viral particles recognized could be used as a risk marker in the development of autoimmune diseases. A autoimunidade 谷 caracterizada pela destrui  o tecidual, que acarreta danos funcionais, causados por c谷lulas autoreativas que escapam dos mecanismos de autotolerancia. Doen as autoimunes podem ser iniciadas por infec  es virais e o estudo da associa  o entre essas viroses e a autoimunidade tem possibilitado melhor conhecimento dos mecanismos moleculares envolvidos nas doen as autoimunes. O v赤rus linfotr車pico de c谷lulas T humano tipo 1 (HTLV-1) 谷 um delta v赤rus que infecta preferencialmente linf車citos. Part赤culas semelhantes aos retrov赤rus foram identificadas em pacientes com doen as autoimunes. Portanto, esta revis o teve por objetivo abordar os principais aspectos envolvendo HTLV-1 com o l迆pus eritematoso sist那mico e artrite reumat車ide. Estudos demonstram que retrov赤rus podem integrar seu material gen谷tico no DNA do hospedeiro, alterando o perfil de express o de genes relacionados a apoptose ou a mol谷culas do sistema imunol車gico. Sabe-se que o HTLV pode causar diferentes manifesta  es cl赤nicas em seus portadores e os mecanismos pelos quais se desencadeiam as doen as autoimunes associadas ao HTLV-1 n o est o bem esclarecidos. Al谷m da perpetua  o e produ  o acentuada de citocinas pr車inf
%K HTLV-1
%K Autoimmune diseases
%K Systemic l迆pus erythematosus
%K Rheumatoid arthritis.
%U http://www.uel.br/revistas/uel/index.php/seminabio/article/view/9586