%0 Journal Article
%T A Protein Concentration Measurement System Using a Flexural Plate-Wave Frequency-Shift Readout Technique
%A Chua-Chin Wang
%A Tzu-Chiao Sung
%A Chia-Hao Hsu
%A Yue-Da Tsai
%A Yun-Chi Chen
%A Ming-Chih Lee
%A I-Yu Huang
%J Sensors
%D 2013
%I MDPI AG
%R 10.3390/s130100086
%X A protein concentration measurement system with two-port flexural plate-wave (FPW) biosensors using a frequency-shift readout technique is presented in this paper. The proposed frequency-shift readout method employs a peak detecting scheme to measure the amount of resonant frequency shift. The proposed system is composed of a linear frequency generator, a pair of peak detectors, two registers, and a subtractor. The frequency sweep range of the linear frequency generator is limited to 2 MHz to 10 MHz according to the characteristics of the FPW biosensors. The proposed frequency-shift readout circuit is carried out on silicon using a standard 0.18 ¦Ìm CMOS technology. The sensitivity of the peak detectors is measured to be 10 mV. The power consumption of the proposed protein concentration measurement system is 48 mW given a 0.1 MHz system clock.
%K FPW
%K frequency-shift readout circuit
%K peak detection
%K resonant frequency
%K immunoglobulin E
%U http://www.mdpi.com/1424-8220/13/1/86