%0 Journal Article
%T Regulatory T cells participation in the infection immunopathogenesis by the Human Immunodeficiency Virus (HIV-1) Participa  o de c谷lulas T regulat車rias (Tregs) na imunopatog那nese da infec  o pelo v赤rus da imunodefici那ncia humana 1 (HIV-1)
%A Isabele Kazahaya Borges
%A Juliana Elisa Lima
%A Paula de Azevedo Oliveira Milanez
%A Sara Santos Bernardes
%J Semina : Ci那ncias Biol車gicas e da Sa迆de
%D 2010
%I Universidade Estadual de Londrina
%X The survival of patients infected with human immunodeficiency virus (HIV-1) is related to the prevention and effective treatment of opportunistic infections. It is known that the main parameters to evaluate the progression of disease caused by HIV-1 is the counting of CD4 + T cells and viral load of HIV-1. Regulatory T cells has been considered the focus of intense research within the immune system as well as in the pathogenesis of several diseases. Natural regulatory T cells (Tregs) CD4+CD25+ act in the modulation of immune activation, functioning as critical mediators of immune homeostasis and self-tolerance. Furthermore, recent studies has shown that the function of Tregs cells is not limited to the prevention of autoimmunity, but is also important to control all forms of immune responses in the context of inflammation, infection, allergy, transplantation and tumor immunity. Many authors have identified Tregs as beneficial effector cells in the context of AIDS, but other researchers disagree. Tregs can exert an important role in the immunopathology of HIV infection due to the suppressor activity on cellular activation and effector function. Thus, this review discusses the molecular and immunological aspects of Tregs in the HIV system. A sobreviv那ncia de pacientes infectados pelo v赤rus da imunodefici那ncia humana (HIV-1) 谷 relacionada 角 preven  o e ao tratamento eficaz de infec  es oportunistas. 谷 conhecido que os principais parametros para avaliar a progress o da doen a causada pelo HIV-1 s o contagem de c谷lulas T CD4+ e carga viral do HIV-1. C谷lulas T regulat車rias t那m sido foco de intensas investiga  es dentro do sistema imunol車gico como tamb谷m na patog那nese de diversas doen as. Sabe-se que as c谷lulas T reguladoras (Tregs) CD4+CD25+FoxP3+ atuam na modula  o da ativa  o imune, funcionando como mediadores cr赤ticos da homeostasia imune e da auto-tolerancia. Al谷m disso, recentes estudos t那m demonstrado que as c谷lulas Tregs n o se limitam 角 preven  o de auto-imunidade, mas s o importantes no controle todas as formas de respostas imunes no contexto de inflama  o, infec  o, alergia, transplantes e imunidade tumoral. Muitos autores t那m identificado as Tregs como c谷lulas efetoras ben谷ficas no contexto da AIDS, por谷m h芍 discordancia. Tregs podem sustentar importante fun  o na imunopatologia da infec  o pelo HIV devido a atividade supressora sobre ativa  o celular e fun  o efetora. Neste contexto, esta revis o aborda os aspectos moleculares e imunol車gicos das Tregs no sistema HIV
%K Tregs
%K HIV
%K CD4
%K AIDS.
%U http://www.uel.br/revistas/uel/index.php/seminabio/article/view/8794