%0 Journal Article
%T Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change
%A Khoshbaten Manouchehr
%A Aliasgarzadeh Akbar
%A Masnadi Koorosh
%A Farhang Sara
%J Saudi Journal of Gastroenterology
%D 2010
%I Medknow Publications
%X Background/Aim: Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting. Materials and Methods: Fifteen patients were enrolled in each group. Liver function tests were done; also, grade of steatosis and pattern of echogenicity of the liver were determined. Patients were followed up by the same evaluation repeated in first, second and third months. Results: Mean age ¡À standard deviation was 43.2 ¡À 10.3 years. Grape seed extract (GSE) significantly improved the grade of fatty liver change; and resulted in significant decrease in alanine aminotransferase in patients receiving the concentrate compared to those receiving vitamin C independently, from the initial grade of steatosis. Conclusions: This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.
%K Grape seed
%K treatment
%K liver function tests
%K liver hemodynamics
%K nonalcoholic fatty liver disease
%K treatment
%U http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2010;volume=16;issue=3;spage=194;epage=197;aulast=Khoshbaten