%0 Journal Article
%T Pluronic and Chitosan based In situ gel system for periodontal application
%A Gupta Himanshu
%A Sharma Aarti
%A Shrivastava Birendra
%J Asian Journal of Pharmaceutics
%D 2009
%I Medknow Publications
%X Aim of this paper is to develop and evaluate a physiologically activated in situ gel for local periodontal application. The gel, when at formulation pH and temperature (pH 6, 25ˇăC) will be at liquid form which will be converted to gel at body pH and temperature (pH 7.4, 37ˇăC) showing ease of administration and prolonged duration of action. Chitosan which was both mucoadhesive as well as pH simulative polymer was used in combination with pluronic F-127 which is a temperature simulated gelation polymer. Prilocaine hydrochloride was used as model drug to check the efficacy of the developed in-situ gel system. Different combination of Chitosan and pluronic F-127 were tested and final combination of 0.5% w/v and 10% w/v of Chitosan and pluronic F-127 respectively were selected and further evaluated for parameters like physicochemical properties, viscosity, gelation pH, gelation temperature, in-vitro release, sterility testing and stability testing. The system thus developed was found to be clear and have good viscosity with prolonged release at pH 7.4 and 37ˇăC. The formulation can be easily packaged and sterilized with method employed. As per ICH guidelines gel was found to be stable and a shelf life of 2 years was assigned to the formulation.
%K Chitosan 150KD
%K in situ gel
%K pluronic F-127
%K periodontal anaesthesia
%K prilocaine hydrochloride
%U http://www.asiapharmaceutics.info/article.asp?issn=0973-8398;year=2009;volume=3;issue=2;spage=94;epage=96;aulast=Gupta