%0 Journal Article
%T Dose-dependent expression of neuronal injury markers during experimental osteoarthritis induced by monoiodoacetate in the rat
%A Joana Ferreira-Gomes
%A Sara Ad£¿es
%A Raquel Sousa
%A Marcelo Mendon£¿a
%A Jos¨¦ Castro-Lopes
%J Molecular Pain
%D 2012
%I BioMed Central
%R 10.1186/1744-8069-8-50
%X OA animals showed the characteristic histopathological changes of the joints and the accompanying nociceptive behaviour, evaluated by the Knee-Bed and CatWalk tests. An increase of ATF-3 expression was detected in the DRG of OA animals as early as 3£¿days after the injection of 1 or 2£¿mg of MIA and 7£¿days after the injection of 0.3£¿mg. NPY expression was increased in animals injected with 1 or 2£¿mg of MIA, at day 3 or in all time-points, respectively. From day 7 onwards there was a massive increase of GAP-43 expression in ATF-3 cells.The expression of the neuronal injury markers ATF-3 and NPY as well as an up-regulation of GAP-43 expression, indicative of peripheral fibre regeneration, suggests that axonal injury and a regeneration response may be happening in this model of OA. This opens new perspectives in the unravelling of the physiopathology of the human disease.
%K Osteoarthritis
%K Pain
%K Mono-iodoacetate
%K ATF-3
%K NPY
%K GAP-43
%K Neuronal injury
%U http://www.molecularpain.com/content/8/1/50/abstract