%0 Journal Article
%T Fibrin¨®geno YA/Y¡ä (gamma A/gamma Prima) caracter¨ªsticas, propiedades y su posible rol en el desarrollo de trastornos cardiovasculares.
%A Oscar Castillo Baquero
%A Andre¨ªna Rivas Mel¨¦ndez
%A Horacio ¨¢vila Ulloa
%J Salus Online
%D 2010
%I Facultad de Ciencias de la Salud, Universidad de Carabobo
%X YA/Y¡ä fibrinogen (gamma A/gamma Prima) - characteristics, and its possible role in the development of cardiovascular disorders.YA/Y¡äfibrinogen (gamma A/gamma Prime) isoform results from alternative splicing of fibrinogen mRNA.This variant constitutes 8% to 15% of plasma fibrinogen. Compared with YA/YA, YA/Y¡äfibrinogen has biochemical and physiological features. YA/Y¡äserves as carrier protein for Factor XIII in plasma and increases the local concentration of this factor in fibrin clots that are more extensively cross-linked by Factor XIII and are more resistant to fibrinolysis. On the other hand, YA/Y¡äcontains a high affinity binding site for thrombin exosite II and inhibits this coagulation factor and is known as antithrombin I. Researchhas shown an association between high levels of YA/Y¡äand coronary artery disease. However, more recent studies reveal that low levels of this variant are related to thrombotic venous disease and this could be explained by a reduction of antithrombin I activity.
%K Y¡ä fibrinogen
%K cardiovascular risk
%K fibrinolysis
%K antithrombin I
%U http://salus-online.fcs.uc.edu.ve/fibrinogeno_gamna_trast_cardio.pdf