%0 Journal Article
%T Excess Maternal Transmission of Type 2 Diabetes Mellitus in South India: Indication from Sibling Recurrence Risk Ratio Analysis
%A Kamakshi Chaithri Ponnaluri
%A Parimala Narne
%A Mohd. Siraj
%A Mohd. Ishaq
%J Asian Journal of Epidemiology
%D 2012
%I Asian Network for Scientific Information
%X Sibling recurrence risk ratio (¦ĖS), defined as the ratio of risk of disease manifestation in siblings of probands compared with risk of disease in general population, is an extensively used measure of familial aggregation. A ¦ĖS>1 is suggestive of familial aggregation. To assess the extent of familial clustering according to parental history of type 2 diabetes mellitus, the sibling recurrence risks (KS) and the sibling recurrence risk ratios (¦ĖS) were estimated in a randomly selected sample of 275 subjects with type 2 diabetes mellitus. A total of 325 out of 1125 siblings were affected giving an overall KS of 28.90% (95%CI: 26.21%-31.51%) and a ¦ĖS of 2.31x (95%CI: 2.09x-2.50x) which is suggestive of a complex aetiology involving both genetic factors and environmental triggers. The KS and the ¦ĖS values were elevated in families with one or two diabetic parents indicating that susceptibility to type 2 diabetes mellitus is transmitted primarily through an affected parent. The risk varied with respect to the status of the probands”Æ parents with KS (49.21%; 95%CI: 43.04%-55.38%) and ¦ĖS (3.94x; 95%CI: 3.41x-4.43x) when both parents were affected being the highest reflecting a predominant influence of the predisposing genetic factors. The ¦ĖS was found to be significantly higher (Z = 2.05; p = 0.04) when the affected parent was the mother (2.59x; 95%CI: 2.20x-3.06x) rather than the father (1.81x; 95%CI: 1.31x-2.31x) indicative of an excess of maternal transmission of type 2 diabetes mellitus. This is the first study on sibling recurrence risk ratio estimates for type 2 diabetes mellitus from India.
%K Type 2 diabetes mellitus
%K sibling recurrence risk ratio
%K familial aggregation
%K maternal transmission
%K South India
%U http://docsdrive.com/pdfs/ansinet/aje/2012/87-94.pdf