%0 Journal Article
%T Study of Antioxidant, Analgesic and Antiulcer Potential of Trichosanthes cucumerina Ethanolic Seeds Extract
%A N.S. Gill
%A Nistha Marwah
%A Rashmi Arora
%A M. Bali
%J Asian Journal of Plant Sciences
%D 2012
%I 
%X The present study was to investigate antioxidant, analgesic and antiulcer effect of ethanolic seeds extract of Trichosanthes cucumerina. Extraction was done by cold maceration method for 72 h using ethanol as solvent. The preliminary phytochemical screening showed the presence of triterpenoids, flavanoids and sterols. The antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. The extract showed maximum scavenging activity 86.2% at 150 ¦Ìg mL-1 by DPPH method as compared to standard antioxidant ascorbic acid. Further extract was studied for antiulcer activity by ethanol induced ulcer model and Non steroidal anti-inflammatory drugs induced method and analgesic activity by Eddy¡¯s hot plate method. Ethanolic extract of Trichosanthes cucumerina cause 72.1 and 57.1% inhibition of ulcer in Non steroidal anti-inflammatory drugs induced model and ethanol induced model at 500 mg kg-1. Result concluded that Ethanolic extract of Trichosanthes cucumerina possess high antiulcer activity which is due to high antioxidant activity and extract also showed potential analgesic activity by Eddy¡¯s hot plate method.
%K 1
%K 1-diphenyl-2-picrylhydrazyl
%K non steroidal anti-inflammatory drugs
%K phytochemical screening
%K ascorbic acid
%U http://docsdrive.com/pdfs/ansinet/ajps/2012/235-240.pdf