%0 Journal Article
%T Synthesis and antimicrobial activity of 4-hydroxy-1-methyl/phenyl-3- (substituted anilinoacetyl) quinolin-2(1H)-one
%A Girish Bolakatti1
%A Manjunatha S. Katagi
%A S.N. Mamledesai
%A Sujatha. M.L.
%A Prakash Dabadi
%A Narayana Miskin.
%J RGUHS Journal of Pharmaceutical Sciences
%D 2012
%I EManuscript Services
%X A series of new 2-quinolone derivatives were synthesized, purifi ed and characterized on the basis of IR, 1H NMR, 13C NMR and Mass spectral studies. Same compounds were evaluated for antimicrobial activity against Staphylococcus aureus, Bacillus substilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Asparagillus niger. Among eighteen synthesized novel compounds, in which five compounds (3a, 3b, 3d, 4a, 4c) shows promising antibacterial activity as compared to Ciprofl oxacin (100 ¦Ìg/ml), however most of them (3a, 3b, 3d, 3e, 4a, 4b, 4d, 4e) showed potent antifungal activity as compared to Fluconazole (100 ¦Ìg/ml)
%U http://www.rjps.in/2012/v2/i1/60