%0 Journal Article
%T Expresi¨®n tisular y niveles s¨¦ricos del factor de crecimiento y transformaci¨®n beta-1 en estomatitis aftosa recurrente
%A Norma Pedrea£¿ez
%A Pablo Ochoa
%A Loida Ponce
%A Robert Tovar
%J Salus Online
%D 2010
%I Facultad de Ciencias de la Salud, Universidad de Carabobo
%X Recurrent aphthous stomatitis is an oral pathology associated with cytokine cascade alterations. Transforming growth factor beta-1 (TGF¦Â-1) is of the uttermost importance in this cascade. Hence, oral mucosal expression and serum levels of TGF¦Â-1 in patients with recurrent aphthous stomatitis were investigated. Nine patients with a diagnosis of recurrent aphthous stomatitis, in acute or remission phase, and five healthy controls were selected. Tissue expression (oral mucosal punch) and serum levels of this cytokine were determined using immunohistochemistry and ELISA techniques. TGF¦Â-1 was expressed in 100% of patients with recurrent aphthous stomatitis in epithelium, submucous and endothelium. In the control group, 40% of the cases expressed TGF¦Â-1 in endothelium and 100% in submucous and epithelium. The percentage of cases with recurrent aphthous stomatitis and strong endothelial expression of TGF¦Â-1 was significantly higher (P<0.05) than those with moderated and weak expression. The intensity of expression in the control group was weak in all layers. Serum levels of TGF¦Â-1 were significantly higher in patients than in the healthy control group (P <0.05). An alteration of systemic or local regulation of the synthesis or liberation of this cytokine could be implicated in the pathogenesis of recurrent aphthous stomatitis
%K Recurrent aphthous stomatitis
%K transforming growth factor beta-1
%K cytokines
%U http://salus-online.fcs.uc.edu.ve/factor_crecimiento_estomatitis.pdf