%0 Journal Article
%T Identificaci車n del ganglio centinela en c芍ncer de colon con t谷cnica de azul patente V.
%A ARGIMIRO RODR赤GUEZ
%A RUB谷N HERN芍NDEZ
%A JOSEFA MAR赤A BRICEˋO
%A ARON KRYGIER
%J Revista Venezolana de Oncolog赤a
%D 2005
%I Scientific Electronic Library Online
%X OBJETIVOS: Estudiar la factibilidad de la detecci車n del ganglio centinela en el c芍ncer de colon, determinando su exactitud diagn車stica y valor en la estadificaci車n de estos pacientes. M谷TODOS: Se incluyeron todos los pacientes con diagn車stico histol車gico y endosc車pico de c芍ncer de colon, excluy谷ndose aquellos con radioterapia o quimioterapia previa, o antecedentes de cirug赤as abdominales. Se inyect車 peritumoralmente y subseroso 1 mL de Azul Patente V , realizando la cirug赤a habitualmente indicada, identificando en el transoperatorio o ex vivo el ganglio centinela. A los ganglios hematoxilina-eosina negativos se les realiz車 inmunohistoqu赤mica. RESULTADOS: Se incluyeron 16 pacientes con c芍ncer de colon. Se identific車 el ganglio centinela en 62,5 % de los casos. Hubo 20 % de falsos negativos. Todos los ganglios centinelas negativos por hematoxilina y eosina lo fueron por inmunohistoqu赤mica. No hubo correlaci車n estad赤sticamente significativa entre las caracter赤sticas propias del tumor y la identificaci車n del ganglio centinela. CONCLUSIONES: La determinaci車n del ganglio centinela es factible en el c芍ncer de colon. Su hallazgo no se relaciona estad赤sticamente con el tama o, grado de diferenciaci車n y ubicaci車n del tumor o valores predeterminados de ant赤geno carcinoembrionario. Hace falta la convalidaci車n del tiempo y estudios comparativos para establecer el valor pron車stico de este procedimiento. OBJECTIVES: Determine the feasibility of sentinel lymph node detection in colon cancer. The diagnostic accuracy of the procedure and its value as a staging tool is also evaluated. METHODS: We included in this series patients with diagnosis of colon cancer made by endoscopy and biopsy. Previous abdominal surgery or radiochemotherapy were considered exclusion criteria. Patent blue dye was injected around the tumor in the subserosa. Surgery was continued in the usual manner. Intraoperatively or after the completion of the surgical procedure (ex-vivo) the sentinel node was identified and sent separately for histopathological analysis. Immunohistochemistry was performed in negative sentinel lymph nodes evaluated with routine hematoxilin-eosin staining. RESULTS: 16 patients with colon cancer were included in this series. Sentinel lymph nodes were identified in 62.5 % of cases. There was a 20 % false negative rate. All sentinel lymph nodes negative with hematoxilin-eosin were negative with immunohistochemical studies. No statistically significant correlation was found between sentinel lymph node identification and tumor characteristics. CONCLUSIONS: Sentinel lymph node ident
%K C芍ncer
%K colon
%K diagn車stico
%K estadiaje
%K ganglio centinela
%K Cancer
%K colon
%K diagnoses
%K stages
%K sentinel lymph node
%U http://wwww.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0798-05822005000400003