%0 Journal Article
%T Design And Evaluation of Gastroretentive Floating Drug Delivery System of Metoprolol Tartrate
%A M. Mohan Varma
%A P. Anita
%J RGUHS Journal of Pharmaceutical Sciences
%D 2012
%I EManuscript Services
%X Drugs that have narrow absorption window in the gastrointestinal tract (GIT) will have poor absorption. For these drugs, gastroretentive drug delivery systems offer the advantage in prolonging the gastric emptying time. Metoprolol tartrate is an antihypertensive drug,it has low elimination half life: 3¨C4 hrs.The floating tablets of metoprolol tartrate were prepared to increase the gastric retention and to improve the bioavailability of the drug. The rapid gastro-intestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to poor bioavailability of the drug. The floating tablets were formulated using HPMC K4M and HPMC K100M as the release retardant polymers, and sodium bicarbonate as the gas generating agent to reduce the floating lag time. The tablets were prepared by direct compression.The formulated tablets were evaluated for weight variation, hardness, friability, swelling index floating lag time, total floating time and dissolution rate in pH 1.2. The floating tablets extended the drug release up to 8 hrs. The drug-polymer interaction was evaluated by fourier transform infrared spectroscopy (FTIR). The FTIR study indicated the lack of drug-polymer interaction. The optimized formulation (F8), containing drug: HPMC K100M, at 1:4 ratio, showed very good result and extended the release up to 8 hours. The drug release from the optimized formulation followed first order kinetics (correlation coefficient, r value 0.981) and non-fickian diffusion (n=0.623). The similarity factor calculated for batch F8(optimized formulation) was 55.46%, and its dissolution profile was similar to the dissolution profile of the branded extended release tablet.
%K Metoprolol
%K Floating tablets
%K HPMC
%K Dissolution.
%U http://www.rjps.in/abs/10.5530/rjps.2012.2.6