%0 Journal Article
%T Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder
%A Paula S Ramos
%A Satria Sajuthi
%A Carl D Langefeld
%A Stephen J Walker
%J Molecular Autism
%D 2012
%I BioMed Central
%R 10.1186/2040-2392-3-4
%X We identified 2,012 genes of known immune-function via Ingenuity Pathway Analysis. Family-based tests of association were computed on the 22,904 single nucleotide polymorphisms (SNPs) from the 2,012 immune-related genes on 1,510 trios available at the Autism Genetic Resource Exchange (AGRE) repository. Several SNPs in immune-related genes remained statistically significantly associated with ASD after adjusting for multiple comparisons. Specifically, we observed significant associations in the CD99 molecule-like 2 region (CD99L2, rs11796490, P£¿=£¿4.01£¿¡Á£¿10-06, OR£¿=£¿0.68 (0.58-0.80)), in the jumonji AT rich interactive domain 2 (JARID2) gene (rs13193457, P£¿=£¿2.71£¿¡Á£¿10-06, OR£¿=£¿0.61 (0.49-0.75)), and in the thyroid peroxidase gene (TPO) (rs1514687, P£¿=£¿5.72£¿¡Á£¿10-06, OR£¿=£¿1.46 (1.24-1.72)).This study suggests that despite the lack of a general enrichment of SNPs in immune function genes in ASD children, several novel genes with known immune functions are associated with ASD.
%K Autism Spectrum Disorders
%K immune loci
%K family-based association analysis
%K single-nucleotide polymorphism
%U http://www.molecularautism.com/content/3/1/4/abstract