%0 Journal Article
%T Variation in the autism candidate gene GABRB3 modulates tactile sensitivity in typically developing children
%A Teresa Tavassoli
%A Bonnie Auyeung
%A Laura C Murphy
%A Simon Baron-Cohen
%A Bhismadev Chakrabarti
%J Molecular Autism
%D 2012
%I BioMed Central
%R 10.1186/2040-2392-3-6
%X Across both tactile sensitivity measures, three SNPs (rs11636966, rs8023959 and rs2162241) were nominally associated with both phenotypes, providing a measure of internal validation. Parent-report scores were nominally associated with six SNPs (P <0.05). Behaviourally measured tactile sensitivity was nominally associated with 10 SNPs (three after Bonferroni correction).This is the first human study to show an association between GABRB3 variation and tactile sensitivity. This provides support for the evidence from animal models implicating the role of GABRB3 variation in the atypical sensory sensitivity in autism spectrum conditions. Future research is underway to directly test this association in cases of autism spectrum conditions.
%K Autism spectrum conditions
%K autistic traits
%K GABA
%K sensory profile
%K tactile sensitivity
%U http://www.molecularautism.com/content/3/1/6/abstract