%0 Journal Article
%T Validity, reliability, and responsiveness of a new short Visual Simplified Respiratory Questionnaire (VSRQ©) for health-related quality of life assessment in chronic obstructive pulmonary disease
%A T Perez
%A B Arnould
%A J-M Grosbois
%A V Bosch
%J International Journal of COPD
%D 2008
%I Dove Medical Press
%X T Perez1, B Arnould2, J-M Grosbois3, V Bosch2, I Guillemin2, M-L Bravo4, M Brun4, A-B Tonnel1 on behalf of TIPHON Study Group1Centre Hospitalier R¨¦gional Universitaire (CHRU), Lille, France; 2Mapi Values, Lyon, France; 3Service de Pneumologie, Centre Hospitalier de B¨¦thune, B¨¦thune, France; 4Boehringer Ingelheim France, Reims C¨¦dex, FranceAbstract: The Visual Simplified Respiratory Questionnaire (VSRQ) was designed to assess health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). It contains eight items: dyspnea, anxiety, depressed mood, sleep, energy, daily activities, social activities and sexual life. Psychometric properties were assessed during a clinical trial that evaluated the impact of tiotropium on HRQoL of COPD patients. These included the determination of structure, internal consistency reliability, concurrent validity with the St George¡¯s Respiratory Questionnaire (SGRQ), test ¨C retest reliability, clinical validity and responsiveness to change over two weeks. Minimal important difference (MID) was calculated; cumulative response curves (CRC) were based on the dyspnea item. Psychometric analyses showed that VSRQ structure was unidimensional. The questionnaire demonstrated good internal consistency reliability (Cronbach¡¯s alpha = 0.84), good concurrent validity with SGRQ (Spearman =  0.70) and clinical validity, good test-retest reproducibility (ICC = 0.77), and satisfactory responsiveness (standardized response mean = 0.57; Guyatt¡¯s statistic = 0.63). MID was 3.4; CRC median value of the ¡®minimally improved¡¯ patients was 3.5. In conclusion, VSRQ brevity and satisfactory psychometric properties make it a good candidate for large studies to assess HRQoL in COPD patients. Further validation is needed to extend its use in clinical practice.Keywords: chronic obstructive pulmonary disease, VSRQ, SGRQ, health-related quality of life, minimal important difference
%U http://www.dovepress.com/validity-reliability-and-responsiveness-of-a-new-short-visual-simplifi-a2706