%0 Journal Article %T Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases %A Luigi Rossi %A Angelo Zullo %A Federica Zoratto %A Anselmo Papa %J Oncology Reviews %D 2012 %I PAGEPress Publications %R 10.4081/oncol.2012.e6 %X Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable. %K liver metastasis %K colorectal cancer %K chemotherapy %K neo-adjuvant chemotherapy %K biological therapy %K bevacizumab %K cetuximab. %U http://www.oncologyreviews.org/index.php/or/article/view/179