%0 Journal Article
%T Deficiency of macrophage migration inhibitory factor (MIF) inhibits cytokine-induced IL-1¦Â generation in murine pancreatic islet cells
%A Stojanovi£¿ Ivana
%A Saksida Tamara
%A Sto£¿i£¿-Gruji£¿i£¿ Stanislava
%J Archives of Biological Sciences
%D 2013
%I Serbian Biological Society
%R 10.2298/abs1301009s
%X In diabetes, pancreatic islets are subjected to high levels of inflammatory mediators that can lead to beta cell destruction. We recently showed that pancreatic islet cells derived from MIF-deficient (MIF-KO) mice are resistant to apoptosis induction by the cytotoxic stimuli of cytokines. Here we show that MIF-KO islets under cytokine (IFN-¦Ã+TNF- ¦Á+IL-1¦Â) stimulation express and secrete significantly lower amounts of IL-1¦Â, while the expression of caspase-1 mRNA is not influenced by MIF deficiency. These data suggest that MIF-KO islets possess an innate defect in the process of IL-1 ¦Â synthesis and secretion.
%K Pancreatic islets
%K Macrophage Migration Inhibitory Factor (MIF)
%K IL-1¦Â
%K caspase-1
%U http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641301009S.pdf