%0 Journal Article
%T Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported malaria
%A Poluga Jasmina
%A Dopsaj Violeta
%A Veljkovi£¿ Milena
%A Maksi£¿ N.
%J Archives of Biological Sciences
%D 2012
%I Serbian Biological Society
%R 10.2298/abs1204577p
%X In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-¦Á) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-¦Á and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-¦Á and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-¦Á and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-¦Á values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenas§Ö, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates.
%K Malaria
%K cytokines
%K TNF-¦Á
%K IL-6
%K parasitemia
%U http://www.doiserbia.nb.rs/img/doi/0354-4664/2012/0354-46641204577P.pdf