%0 Journal Article
%T Non-specific biological markers as a screening test for diagnostic of extrapulmonary tuberculosis
%A Stevanovic G.
%A Pelemis M.
%A Pelemis S.
%A Pavlovic M.
%J Archives of Biological Sciences
%D 2012
%I Serbian Biological Society
%R 10.2298/abs1202489s
%X Serum concentrations of adenosine deaminase were determined in 223 febrile patients. In 62, we discovered extrapulmonary tuberculosis. Serum levels of immunoglobulin G were monitored in 287 febrile patients, and 68 had extra-pulmonary tuberculosis. Serum concentrations of adenosine deaminase were significantly higher in patients with tuberculosis compared to other patients with fever of unknown origin. Serum concentrations declined during antituberculosis therapy. A correlation with the localization of infection was not found. Levels of immunoglobulin G were higher in patients with tuberculosis. Both tests had high sensitivity and specificity and could therefore be used for screening extrapulmonary tuberculosis; however, they can only be interpreted adequately following a full clinical investigation.
%K Tuberculosis
%K adenosine deaminase
%K immunoglobulin G
%K fever of unknown origin
%K laboratory tests
%U http://www.doiserbia.nb.rs/img/doi/0354-4664/2012/0354-46641202489S.pdf