%0 Journal Article
%T Spatial Tumor-Immune Modeling
%A L. G. de Pillis
%A D. G. Mallet
%A A. E. Radunskaya
%J Computational and Mathematical Methods in Medicine
%D 2006
%I Hindawi Publishing Corporation
%R 10.1080/10273660600968978
%X In this paper, we carry out an examination of four mechanisms that can potentially lead to changing morphologies in a growing tumor: variations in nutrient consumption rates, cellular adhesion, excessive consumption of nutrients by tumor cells and immune cell interactions with the tumor. We present numerical simulations using a hybrid PDE-cellular automata (CA) model demonstrating the effects of each mechanism before discussing hypotheses about the contribution of each mechanism to morphology change.
%U http://www.hindawi.com/journals/cmmm/2006/821675/abs/