%0 Journal Article
%T Efecto antitumoral del extracto acuoso de Bomarea cornigera (Alstroemeriaceae) en sarcomas inducidos en ratones Antitumoral effect of the aqueous extracts of Bomarea cornigera (Alstroe- meriaceae) on the sarcoma induced in mice
%A Christian Villanueva
%A Claudia Rodr赤guez
%A Karol Lavado
%A Melissa Barbieri
%J Revista Peruana de Biolog赤a
%D 2011
%I Ciudad Universitaria, Lima
%X Se investig車 el efecto antitumoral del extracto acuoso del bejuco Bomarea cornigera. Ratones de la cepa Swiss albina fueron inoculados con la l赤nea tumoral TG-180 por 15 d赤as; luego del cual se separaron en 5 grupos (n=5 por grupo). Se administro intraperitonealmente ciclofosfamida (control positivo), agua destilada (control negativo) y el extracto en concentraciones de 1X, 2X y 4X; se evalu車 la morbilidad, mortalidad, el peso y la longitud del sarcoma. Se encontr車 un efecto inhibidor del extracto de B. cornigera en el desarrollo del tumor s車lido en ratones en los cuales se les transplanto el sarcoma TG-180. Las tasas de inhibici車n fueron 87,44 y 8,52% despu谷s de 17 d赤as de tratamiento considerando la dosis 1X (m芍s baja) y 2X (intermedia), respectiva- mente. Estos resultados sugieren que la administraci車n de extracto acuoso de B. cornigera v赤a intraperitoneal puede ser 迆til como inhibidor del c芍ncer. We investigated antitumor effect of aqueous extract of Bomarea cornigera. Swiss albino mice strain were inoculated with tumor cell line TG-180 for 15 days, after which they were separated into 5 groups (n= 5 per group). Cyclophosphamide was administered intraperitoneally (positive control), distilled water (negative control) and the aqueous extract at concentrations of 1X, 2X and 4X; the morbidity, mortality, weight and length of the sarcoma were assessed. We found an inhibitory effect of extract of B. cornigera in the development of solid tumor in mice where the TG-180 sarcoma was transplanted. The inhibition rates were 87.44 and 8.52% after 17 days of treatment, considering 1X dose (lowest) and 2X (intermediate), respectively. These results suggest that administration of aqueous extract of B. cornigera intraperitoneally may be useful as a cancer inhibitor.
%K Bomarea cornigera
%K antitumor
%K planta medicinal
%K TG-180
%K c芍ncer.
%U http://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/16