%0 Journal Article
%T Immediate effect of intensive atorvastatin therapy on lipid parameters in patients with acute coronary syndrome
%A Dagmar Vondrakova
%A Petr Ostadal
%A Andreas Kruger
%J Lipids in Health and Disease
%D 2010
%I BioMed Central
%R 10.1186/1476-511x-9-71
%X We have analyzed a group of 114 patients with ACS (mean age 63.7; females 25.4%). Atorvastatin 80 mg was administered at admission and then once daily for the rest of hospitalization. The levels of total cholesterol (TC), LDL-cholesterol (LDL), HDL-cholesterol (HDL), and triglycerides (TG) were measured at admission (D0), and then every morning of hospitalization (D1, D2).The mean entry values (D0) of TC, LDL, HDL and TG (in mmol/L) were 5.24, 3.26, 1.07 and 1.31, respectively. The therapy with atorvastatin 80 mg resulted in a decrease of TC levels in the first morning (D1) by 6.1% and in the second morning (D2) by 13.2% (p < 0.001 for all comparisons with the entry value D0); LDL was decreased by 5.8% (D1) and 15.6% (D2) (p < 0.001 vs. D0); the level of HDL was decreased by 7.5% (D1) and 12.1% (D2) (p < 0.001 vs. D0). In contrast, the TG level was higher in the first morning (D1) by 20.6% and in the following morning (D2) by 25.5% (p < 0.05 vs. D0).We have shown that intensive statin therapy started at admission in ACS patients has a highly significant, immediate effect on all monitored lipid levels. Since TC and LDL levels were decreased as predicted, reduction in HDL and increase in TG levels suggest a different acute effect of high-dose statin on lipid levels in comparison with long-term treatment of ACS patients.Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, have been for two decades successfully used in the therapy of hypercholesterolemia and stable ischemic heart disease. During the recent years, several large clinical trials were presented showing a beneficial effect of statin therapy started in acute coronary syndrome (ACS) patients after clinical stabilization or before discharge [1-3]. Moreover, it has been shown that intensive (high-dose) statin therapy is superior to standard-dose: in the meta-analysis intensive statin therapy decreased not only the incidence of cardiovascular events but also total mortality in patients a
%U http://www.lipidworld.com/content/9/1/71