%0 Journal Article
%T Effect of 50£¿Hz electric field in diacylglycerol acyltransferase mRNA expression level and plasma concentration of triacylglycerol, free fatty acid, phospholipid and total cholesterol
%A Takuya Hori
%A Shinji Harakawa
%A Shirley M Herbas
%A Yoshiko Y Ueta
%A Noboru Inoue
%A Hiroshi Suzuki
%J Lipids in Health and Disease
%D 2012
%I BioMed Central
%R 10.1186/1476-511x-11-68
%X The test was based on comparison between mice post treated with 50£¿Hz EF of 45£¿kV/m intensity for 30£¿min per day for 11£¿days or without EF. DGATs mRNA expression was analyzed by real-time quantitative polymerase chain reaction.There was no difference in the gene expression level of DGAT1 in liver and intestines. The DGAT2 gene expression level in liver derived from mice treated with EF was significantly lower than those in the control (P£¿<£¿0.001). Both plasma total cholesterol (P£¿<£¿0.01) and phospholipid (P£¿<£¿0.05) in the group exposed to EF were lower than those in the control, but there was no difference in triacylglycerol or free fatty acid levels.Exposure to 50£¿Hz EF decrease the plasma levels of total cholesterol and phospholipids, and downregulated DGAT2 mRNA expression in liver. The mechanisms for the effects of EF on lipid metabolism are not well understand yet, but altered DGAT2 activity may be involved.
%K Diacylglycerol O-acyltransferase
%K Electric field
%U http://www.lipidworld.com/content/11/1/68/abstract