%0 Journal Article
%T Imbalance in superoxide dismutase/thioredoxin reductase activities in hypercholesterolemic subjects: relationship with low density lipoprotein oxidation
%A Paula Rossini Augusti
%A Amanda Roggia Ruviaro
%A Andr¨¦ia Quatrin
%A Sabrina Somacal
%A Greicy Michelle Marafiga Conterato
%A Juliana Tanara Vicentini
%A Marta Medeiros Frescura Duarte
%A Tatiana Emanuelli
%J Lipids in Health and Disease
%D 2012
%I BioMed Central
%R 10.1186/1476-511x-11-79
%X Serum lipids, highly sensitive C-reactive protein (hs-CRP), lipid and protein oxidation, oxidized LDL (LDLox) and LDLox autoantibodies (LDLoxAB) levels and enzymes activities were measured in a total of 116 subjects that were divided into the following groups according to their LDL levels: low-LDL group (LDL£¿<£¿100£¿mg/dL, n£¿=£¿23), intermediate-LDL group (LDL 100¨C160£¿mg/dL, n£¿=£¿50) and high-LDL group (LDL£¿>£¿160£¿mg/dL, n£¿=£¿43).The LDLox and hs-CRP levels increased in the high-LDL group (2.7- and 3.7- fold, respectively), whereas the intermediate and high-LDL groups had higher LDLoxAB (2.2- and 3.1-fold) when compared to low-LDL group (p£¿<£¿0.05). Similarly, SOD activity, the atherogenic index (AI) and protein oxidation were also higher in the intermediate (1.3-, 1.3- and 1.2-fold) and high-LDL (1.6-, 2.3- and 1.6-fold) groups when compared to the low-LDL group (p£¿<£¿0.05). Lipid oxidation and SOD/TrxR-1 ratio increased only in the high-LDL group (1.3- and 1.6-fold) when compared to the low-LDL group (p£¿<£¿0.05). The SOD/TrxR-1 ratio was positively correlated to TBARS (r£¿=£¿0.23, p£¿<£¿0.05), LDLox (r£¿=£¿0.18, p£¿<£¿0.05), LDLoxAB (r£¿=£¿0.21, p£¿<£¿0.05), LDL (r£¿=£¿0.19, p£¿<£¿0.05) and AI (r£¿=£¿0.22, p£¿<£¿0.05). PON1 and TrxR-1 activities were similar among groups.Some oxidative events initiate when LDL levels are clinically acceptable. Moreover, hypercholesterolemic patients have an imbalance in SOD and TrxR-1 activities that is positively associated to LDL oxidation.
%K Atherogenic index
%K Hypercholesterolemia
%K Oxidized low density lipoprotein
%K Superoxide dismutase
%K Thioredoxin reductase
%U http://www.lipidworld.com/content/11/1/79/abstract