%0 Journal Article
%T Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives
%A Jorge Trilleras
%A Efra¨Ēn Polo
%A Jairo Quiroga
%A Justo Cobo
%A Manuel Nogueras
%J Applied Sciences
%D 2013
%I MDPI AG
%R 10.3390/app3020457
%X A series of new 1,3-diaryl-5-(1-phenyl-3-methyl-5-chloropyrazol-4-yl)-4,5-dihydropyrazole derivatives have been synthesized under sonication conditions in ethanol or methanol/glacial acetic acid mixture (5/1 ratio) with two equivalents of hydrazines and seven kinds of chalcone-like heteroanalogues obtained from 5-chloro-3-methyl-1-phenyl-1 H-pyrazole-4-carbaldehyde. The structures were established on the basis of NMR, IR, MS and element analysis. This method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times (2¨C20 min) and good yields (65%¨C80%).
%K pyrazolines
%K cyclocondensation
%K sonication
%K chalcones
%K hydrazines
%U http://www.mdpi.com/2076-3417/3/2/457