%0 Journal Article
%T Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol =Caracter¨ªsticas do carcinoma bucal de c¨¦lulas escamosas em usu¨¢rios ou n o usu¨¢rios de tabaco e ¨¢lcool
%A Scheidt
%A Juliana Hintz Germanos et al.
%J Revista Odonto Ci¨ºncia
%D 2012
%I Editora da Pontif¨ªcia Universidade Cat¨®lica do Rio Grande do Sul (EDIPUCRS)
%X O tabaco e o ¨¢lcool s o os principais fatores etiol¨®gicos extr¨ªnsecos associados ¨¤ g¨ºnese do carcinoma bucal de c¨¦lulas escamosas (CCE), mas n o est¨¢ claro se estes fatores interferem nas caracter¨ªsticas cl¨ªnico-patol¨®gicas, moleculares ou no progn¨®stico da doen a. No presente estudo, essas caracter¨ªsticas foram revisadas, estabelecendo-se compara  es entre as les es de pacientes usu¨¢rios ou n o de tabaco e ¨¢lcool. Observou-se que carcinomas bucais de n o fumantes e n o etilistas ocorrem, preferencialmente, em pacientes do sexo feminino, em faixa et¨¢ria inferior a 50 ou superior 70 anos. Neste grupo de indiv¨ªduos, as les es tendem a ser menos agressivas e apresentam melhor progn¨®stico. O tabagismo e o etilismo tamb¨¦m parecem influenciar as caracter¨ªsticas moleculares do carcinoma bucal, uma vez que muta  es da prote¨ªna p53 nas les es t¨ºm sido associadas a esses fatores de risco. A compreens o das diferen as entre os CCE bucais desses dois grupos de pacientes pode contribuir para uma melhor abordagem e avan os no desenvolvimento de medidas terap¨ºuticas mais adequadas frente a esta neoplasia. Tobacco and alcohol are the main extrinsic etiological factors for the genesis of oral squamous cell carcinoma (SCC), but it is still not clear if the presence of these factors interfere with clinical, pathologic and molecular characteristics or with the prognosis of the disease. In the present study, these characteristics were reviewed, establishing comparisons between the lesions of patients exposed and not exposed to tobacco and alcohol. We observed that oral SCC in non smokers and non alcohol drinkers occur mainly in female patients, under 50 or over 70 years old. The lesions tend to be less aggressive in this group of patients and have a better prognosis. The molecular characteristics of these malignant tumors also appear to be influenced by the presence of these habits, once mutations of p53 have been associated with tobacco and alcohol use. The understanding of the differences between the neoplasms of these two groups of patients can contribute to the management of this cancer, which could lead to advances in the determination of more appropriate therapeutic measures.
%K CARCINOMA DE C¨¦LULAS ESCAMOSAS
%K ESTOMATOLOGIA CL¨ªNICA
%K NEOPLASIAS BUCAIS
%U http://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/9802/7690