%0 Journal Article
%T Omega-3 polyunsaturated fatty acids enrichment alters performance and immune response in infectious bursal disease challenged broilers
%A Elham Maroufyan
%A Azhar Kasim
%A Mahdi Ebrahimi
%A Tech Loh
%A Mohd Bejo
%A Hailemariam Zerihun
%A Fatemeh Hosseni
%A Yong Goh
%A Abdoreza Farjam
%J Lipids in Health and Disease
%D 2012
%I BioMed Central
%R 10.1186/1476-511x-11-15
%X A total of 300 day old male broiler chicks were assigned to four dietary n-3 PUFA ascending levels as the treatment groups (T1: 0.5; T2: 8.0; T3: 11.5; T4: 16.5) using combinations of tuna oil and sunflower oil. All diets were isocaloric and isonitrogenous. On day 28, all birds were challenged with IBD virus. Antibody titer, cytokine production, bursa lesion pre and post-challenge and lymphoid organ weight were recorded.On d 42 the highest body weight was observed in the T2 and T3 and the lowest in T4 chickens. Feed conversion ratio of the T2 broilers was significantly better than the other groups. Although productive parameters were not responded to the dietary n-3 PUFA in a dose-dependent manner, spleen weight, IBD and Newcastle disease antibody titers and IL-2 and IFN-¦Ã concentrations were constantly elevated by n-3 PUFA enrichment.Dietary n-3 PUFA enrichment may improve the immune response and IBD resistance, but the optimum performance does not coincide with the optimum immune response. It seems that dietary n-3 PUFA modulates the broiler chicken performance and immune response in a dose-dependent manner. Thus, a moderate level of dietary n-3 PUFA enrichment may help to put together the efficiency of performance and relative immune response enhancement in broiler chickens.There has been fast growth in the global interest to the effects of diet on various aspects of immune function. Typically, different research groups have assessed different nutrients, each using different animal models. Most of these models focus on selected aspects of immune function without assessing the other functions. It is therefore always difficult to understand the broader modulating influence for instance on the productive parameters. In modern poultry industry, however, within commonly used feed there is an oversupply of n-6 polyunsaturated fatty acids (PUFA) and an undersupply of n-3 PUFA, causing an imbalance in the corn-soybean diet. Consumption of n-3 PUFA, resulted in incorporat
%K n-3 PUFA
%K immune response
%K IBD
%K broiler
%U http://www.lipidworld.com/content/11/1/15