%0 Journal Article
%T The relation between serum lipids and lutein and zeaxanthin in the serum and retina: results from cross-sectional, case-control and case study designs
%A Lisa M Renzi
%A Billy R Hammond
%A Melissa Dengler
%A Richard Roberts
%J Lipids in Health and Disease
%D 2012
%I BioMed Central
%R 10.1186/1476-511x-11-33
%X In all experiments, lipoproteins were measured enzymatically from plasma, and MP optical density (MPOD) was measured using customized heterochromatic flicker photometry. Experiment 1: Relations between serum L and Z, MPOD and lipoprotein levels. 108 young, healthy subjects (M = 23.2, SD = 4.12 years) participated. Lipoprotein levels and MPOD were measured. In a subset of 66 participants, serum L and Z levels were also measured using high-performance liquid chromatography. Experiment 2: Relations between lipoprotein levels and MPOD in statin users. 20 subjects (M = 58.05, SD = 11.08 years) taking statin medication and 20 subjects (M = 57.95, SD = 11.03 years) not taking satin were recruited for participation. MPOD and lipoprotein levels were measured. Experiment 3: lowering lipoprotein levels to impact MPOD. One individual (aged 41 years) with high MP density adhered first to an atorvastatin regimen, then, after a wash-out period, to a rosuvastatin regimen.Experiment 1: HDL were significantly (p < 0.05) related to MPOD (r = 0.33), to serum L (r = 0.36) and to serum Z (r = 0.26). MPOD was also significantly related to total cholesterol (r = 0.19). Experiment 2: MPOD was not lower in statin users when compared to matched non-statin users, but MPOD decreased significantly with increased duration of statin use (r = £¿0.63). Experiment 3: Administration of a statin regimen reduced MPOD with atorvastatin (p < 0.05) but not with rosuvastatin.Serum xanthophylls, retinal xanthophylls and lipoprotein concentrations are significantly related, and changing lipoprotein levels may impact levels of retinal xanthophylls.Approximately 600-800 different carotenoids exist [1,2] and serve a multitude of functions such as light harvesting for plant photosynthesis and protection from free-radical damage (for review, see [1-3]). Carotenoids cannot be synthesized by the majority of animal species de novo and must, consequently, be consumed in the diet. Of the 600-800 carotenoids that have al
%K Macular pigment
%K Lipoproteins
%K Statins
%K Lutein
%K Zeaxanthin
%U http://www.lipidworld.com/content/11/1/33