%0 Journal Article
%T Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
%A Elin Strand
%A Bodil Bj£¿rndal
%A Ottar Nyg£¿rd
%A Lena Burri
%A Christ Berge
%A Pavol Bohov
%A Bj£¿rn J Christensen
%A Kjetil Berge
%A Hege Wergedahl
%A Asgaut Viste
%A Rolf K Berge
%J Lipids in Health and Disease
%D 2012
%I BioMed Central
%R 10.1186/1476-511x-11-82
%X After 50£¿weeks n-3 PUFA levels were increased by TTA and FO in the heart, whereas liver levels were reduced following TTA administration. TTA was associated with a decrease in arachidonic acid, increased activities of carnitine palmitoyltransferase II, fatty acyl-CoA oxidase, glycerol-3-phosphate acyltransferase, and fatty acid synthase in the heart. Furthermore, cardiac Ucp3 and Cact mRNA was upregulated.Long-term treatment with the pan-PPAR agonist TTA or high-dose FO induced marked changes in PUFA composition and enzymatic activity involved in FA metabolism in the heart, different from liver. Changes included increased FA oxidation and a selective increase in cardiac n-3 PUFA.
%K Heart metabolism
%K Peroxisome proliferator-activated receptor
%K Polyunsaturated fatty acids
%K Tetradecylthioacetic acid
%U http://www.lipidworld.com/content/11/1/82/abstract